Drug Eruption, Fixed

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Image of Drug Eruption, Fixed

VisualDx images show variation in age, skin color, and disease stage. VisualDx has 152 images of Drug Eruption, Fixed.

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Pediatrics Complete

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ICD Codes

L27.1 – Localized skin eruption due to drugs and medicaments taken internally

693.0 – Dermatitis due to drugs and medicines taken internally


Fixed drug eruption (FDE) is an adverse drug reaction manifested by skin lesions occurring at the same body site each time the individual is re-exposed to the specific drug. It is most frequently solitary but may sometimes be multiple. Lesions are usually asymptomatic but may cause burning or pruritus. Sometimes these lesions will form blisters. Post-inflammatory hyperpigmentation is common.

While over 100 drugs have been implicated in causing FDE, commonly associated drugs include trimethoprim-sulfamethoxazole (and other sulfonamides), naproxen, ibuprofen, tetracyclines, other antibiotics (ampicillin, metronidazole), barbiturates, oral contraceptives, quinine, and phenolphthalein.

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