Ichthyosis Vulgaris

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Image of Ichthyosis Vulgaris

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Q80.0 – Ichthyosis vulgaris

254157005 – Ichthyosis vulgaris


Ichthyosis vulgaris is a common, autosomal dominantly inherited condition of abnormal cornification. There is altered profilaggrin expression, leading to scaling and desquamation. It is often seen in association with atopic dermatitis and keratosis pilaris. This disorder is associated with extreme dryness of the skin and presents as fine, fish-skin-like scale. It is more prominent in winter and in climates with low relative humidity. The condition usually begins in childhood between 3 and 12 months of age and follows a favorable course in which the scaling alleviates in intensity by adulthood. There is no known race or sex predilection. Hydration, lubrication, and keratolysis are the mainstays of therapy.

There is an acquired form of ichthyosis vulgaris that is rare. It manifests in adulthood and is associated with systemic disease, including malignancy.

For more information, see OMIM.

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