Nevus Sebaceus

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Q85.9 – Phakomatosis, unspecified

52298009 – Linear sebaceous nevus


Nevus sebaceus (of Jadassohn) is a common hamartomatous malformation that is usually present at birth or develops in early childhood. Its presence may be subtle and not be noted until later childhood or adolescence, when it thickens due to hormonal influence. It consists of a yellow to orange oval or linear verrucous plaque, most often on the scalp or, more rarely, the forehead and neck. Most lesions are sporadic. There is no predilection for either sex or any ethnicity. Removal, if not cosmetically a problem, is recommended before adulthood due to the small risk of a malignancy developing within the lesion during adulthood. In the past, the risk of development of basal cell carcinoma within lesions was approximated at 10%, though this is now considered to be an overestimation. Other benign adnexal neoplasms, including trichoblastoma and syringocystadenoma papilliferum, occur more frequently within the lesion. In very rare cases, sebaceous or apocrine carcinomas can occur within nevus sebaceous.

A small number of patients with this lesion will have nevus sebaceus syndrome, which is analogous to epidermal nevus syndrome. They may manifest neurologic, skeletal, or ocular abnormalities.

For more information, see OMIM.

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