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ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferencesView all Images (13)
Acquired hypertrichosis lanuginosa
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Other Resources UpToDate PubMed

Acquired hypertrichosis lanuginosa

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Contributors: Drew J. Klug BS, Jason E. Hawkes MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed

Synopsis

Hypertrichosis lanuginosa acquisita (HLA), or malignant down, is a rare condition characterized by the appearance of lanugo hairs in generalized areas of skin. Lanugo hairs are fine hairs with little or no pigment and resemble the fine hair seen in some infants shortly after birth. HLA commonly affects skin sites with little to no hair growth, such as the nose and smooth, non-hair-bearing (glabrous) skin of the face.

HLA is classically associated with lung, breast, and colorectal carcinomas, but has been described in association with a variety of solid tumors. HLA due to internal malignancy shows a strong female predominance and typically occurs between the ages of 40-70 years. HLA may be accompanied by additional paraneoplastic signs or manifestations of internal disease, such as glossitis, taste disturbances, lymphadenopathy, acanthosis nigricans, and the sudden appearance of multiple seborrheic keratoses (ie, sign of Leser-Trélat).

Hair growth can occur up to 2.5 years before the malignancy is identified or up to 5 years after the cancer diagnosis. The etiology of tumor-associated HLA is presumed to be the result of a tumor-secreted product, though specific biochemical or hormonal causes have not been identified to date.

Codes

ICD10CM:
L68.1 – Acquired hypertrichosis lanuginosa

SNOMEDCT:
25967007 – Hypertrichosis lanuginosa

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Hirsutism – This type of excessive hair growth occurs in females and is distributed in a male pattern. Unlike HLA, the excessive hairs in hirsutism are thicker, terminal hairs. Patients with hirsutism may also have physical findings suggestive of virilization.
  • Hypertrichosis lanuginosa congenita – Excessive lanugo hairs are present at birth or shortly thereafter and do not resolve with increased age.
  • Acquired hypertrichosis – This type of hair growth is characterized by the development of thick, coarse terminal hairs secondary to medications (eg, cyclosporine, streptomycin, penicillin, phenytoin, spironolactone, diazoxide, minoxidil, interferon, and corticosteroids) or metabolic / endocrine disorders (eg, thyroid dysfunction, anorexia nervosa, HIV/AIDS, and Cushing syndrome).
  • Becker nevus – A localized smooth muscle hamartoma that typically presents as a large hyperpigmented patch with increased thick, terminal hairs on the upper extremities or trunk.

Best Tests

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Therapy

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References

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Last Updated: 12/10/2015
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Acquired hypertrichosis lanuginosa
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Acquired hypertrichosis lanuginosa : Hypertrichosis, Lanugo hairs
Clinical image of Acquired hypertrichosis lanuginosa
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