Acquired ichthyosis - Immunocompromised, HIV and AIDS
AI is often seen in HIV infection, usually with a low CD4+ count, and not necessarily associated with malignancy.
AI may be seen with chronic metabolic disturbances (malnutrition, malabsorption, renal failure, hyperparathyroidism, hypopituitarism, hypothyroidism, and diabetes). It also occurs on occasion with connective tissue disease (eg, systemic lupus and dermatomyositis) as well as with sarcoidosis, Hansen's disease, and post-bone marrow transplant.
Drug-induced AI may be caused by cholesterol-lowering agents, butyrophenones, dixyrazine, maprotiline, cimetidine, allopurinol, hydroxyurea, and clofazimine.
Coincident hair loss may occur, as may pruritus or a burning sensation. Symptoms usually improve in a warm, moist climate.
Disease severity depends upon the course of the associated disorder. AI often remits after treatment of underlying malignancy.
L85.0 – Acquired ichthyosis
8691004 – Acquired ichthyosis
- Consider X-linked ichthyosis in males, which has a darker scale and involves the popliteal and antecubital fossae. There are other rare ichthyotic skin disorders, usually present at birth.
- Eczema craquele
- Atopic dermatitis
- Lamellar ichthyosis