A coagulation disorder caused by abnormal fibrinogen function. Can be familial or acquired. Acquired form is associated with cirrhosis, hepatitis, obstructive jaundice (biliary obstruction), immune-mediated disorders, multiple myeloma, hepatoma, and in a small number of patients malignancies (liver tumors, renal cell carcinoma). In severe liver disease, there may be an increased amount of sialic acid combined with fibrinogen, which can markedly inhibit clotting ability. This may lead to bleeding, often in mucosal and soft tissues, and thrombosis.