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Acquired dysfibrinogenemia
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Acquired dysfibrinogenemia

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Synopsis

A coagulation disorder caused by abnormal fibrinogen function. Can be familial or acquired. Acquired form is associated with cirrhosis, hepatitis, obstructive jaundice (biliary obstruction), immune-mediated disorders, multiple myeloma, hepatoma, and in a small number of patients malignancies (liver tumors, renal cell carcinoma). In severe liver disease, there may be an increased amount of sialic acid combined with fibrinogen, which can markedly inhibit clotting ability. This may lead to bleeding, often in mucosal and soft tissues, and thrombosis.

Codes

ICD10CM:
D65 – Disseminated intravascular coagulation [defibrination syndrome]

SNOMEDCT:
111589005 – Dysfibrinogenemia

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Last Updated: 03/16/2016
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Acquired dysfibrinogenemia
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Acquired dysfibrinogenemia : Bleeding time prolonged, PT prolonged
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