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Acquired ichthyosis - Immunocompromised, HIV and AIDS
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Acquired ichthyosis - Immunocompromised, HIV and AIDS

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Contributors: Marvin Turck MD
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Synopsis

Acquired ichthyosis (AI) is a rare condition usually associated with underlying disease. It is clinically similar to ichthyosis vulgaris, a benign hereditable trait manifest in childhood. AI may be associated with malignancy, nonmalignant conditions, and medications. The most common associated malignancy is Hodgkin's disease. AI has also been reported with non-Hodgkin's lymphomas; multiple myeloma; mycosis fungoides; carcinoma of the breast, lung, cervix, and liver; and sarcomas, including Kaposi sarcoma. The skin changes often occur simultaneously or after the diagnosis of malignancy.

AI is often seen in HIV infection, usually with a low CD4+ count, and not necessarily associated with malignancy.

AI may be seen with chronic metabolic disturbances (malnutrition, malabsorption, renal failure, hyperparathyroidism, hypopituitarism, hypothyroidism, and diabetes). It also occurs on occasion with connective tissue disease (eg, systemic lupus and dermatomyositis) as well as with sarcoidosis, Hansen's disease, and post-bone marrow transplant.

Drug-induced AI may be caused by cholesterol-lowering agents, butyrophenones, dixyrazine, maprotiline, cimetidine, allopurinol, hydroxyurea, and clofazimine.

Coincident hair loss may occur, as may pruritus or a burning sensation. Symptoms usually improve in a warm, moist climate.

Disease severity depends upon the course of the associated disorder. AI often remits after treatment of underlying malignancy.

Codes

ICD10CM:
L85.0 – Acquired ichthyosis

SNOMEDCT:
8691004 – Acquired ichthyosis

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Rare differential:

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 02/09/2018
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Acquired ichthyosis - Immunocompromised, HIV and AIDS
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Acquired ichthyosis : Dry skin, Widespread, Fine fish scale plaques
Clinical image of Acquired ichthyosis
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