ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferences
Acquired pseudohypoaldosteronism
Print
Other Resources UpToDate PubMed

Acquired pseudohypoaldosteronism

Print Images (1)
Contributors: Joon B. Kim BS, Catherine Moore MD, Michael W. Winter MD
Other Resources UpToDate PubMed

Synopsis

Acquired pseudohypoaldosteronism is a rare secondary disorder of electrolyte equilibrium defined as a state of resistance to aldosterone in renal tubules. It typically develops in infants but may occur in any age group following a urinary tract infection or renal transplant or in a patient with a urinary tract abnormality. Patients experience hyponatremia from the severe volume depletion of urinary salt wasting, hyperkalemia, hydronephrosis, metabolic acidosis, and weight loss. Plasma aldosterone levels may be normal or elevated, and renin levels are elevated. Target tissues develop resistance to mineralocorticoids. This resistance results in aldosterone having a markedly diminished effect on its targeted receptors. Usually, renal and adrenal functions are normal.

Twenty percent of pseudohypoaldosteronism cases are due to familial causes; the acquired form is discussed here.

Treatment involves eliminating the underlying cause and providing supportive care for the associated electrolyte disturbances.

Codes

ICD10CM:
E34.9 – Endocrine disorder, unspecified

SNOMEDCT:
77098009 – Pseudohypoaldosteronism

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

References

Subscription Required

Last Reviewed: 04/25/2019
Last Updated: 05/15/2019
Copyright © 2019 VisualDx®. All rights reserved.
Acquired pseudohypoaldosteronism
Print 1 Images
Acquired pseudohypoaldosteronism : Failure to thrive, Hyperkalemia, Hyponatremia, Metabolic acidosis, Weight loss, Aldosterone elevated
Copyright © 2019 VisualDx®. All rights reserved.