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Acute graft-versus-host disease in Infant/Neonate
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Acute graft-versus-host disease in Infant/Neonate

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Contributors: Craig N. Burkhart MD, Dean Morrell MD, Lowell A. Goldsmith MD, MPH, Nancy Esterly MD
Other Resources UpToDate PubMed

Synopsis

Graft-versus-host disease (GVHD) refers to organ dysfunction resulting from the introduction of foreign immunocompetent lymphocytes or bone marrow tissue (the graft) into an immunologically defective host. Acute GVHD in infants is usually secondary to engraftment of maternally transmitted or transfusion-derived T lymphocytes in infants with severe combined immunodeficiency (SCID). Acute disease typically presents as a morbilliform eruption that may progress to erythroderma or a toxic epidermal necrolysis-like picture.

Codes

ICD10CM:
D89.810 – Acute graft-versus-host disease

SNOMEDCT:
402355000 – Acute graft-versus-host disease

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

In infants with a toxic epidermal necrolysis-like picture:

Best Tests

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Management Pearls

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Therapy

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References

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Last Updated: 01/11/2018
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Acute graft-versus-host disease in Infant/Neonate
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Acute graft-versus-host disease : Abdominal pain, Diarrhea, Fever, Hepatomegaly, Rash, Neck, Shoulder, Hyperbilirubinemia, Anorexia, Plantar feet, Palms, Ears
Clinical image of Acute graft-versus-host disease
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