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Acute hemorrhagic edema of infancy - Skin
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Acute hemorrhagic edema of infancy - Skin

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Contributors: Craig N. Burkhart MD, Dean Morrell MD, Lowell A. Goldsmith MD, MPH, Nancy Esterly MD
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Synopsis

Acute hemorrhagic edema of infancy (AHEI), also known as acute hemorrhagic edema of childhood or post-infectious cockade purpura, is a leukocytoclastic vasculitis affecting children aged 4 months to 2 years. It is characterized by edematous hemorrhagic lesions of the head and distal extremities and usually noted after an upper respiratory tract infection and/or a course of antibiotics.

Although the cause is unknown, it is thought to be an immune complex-related reaction to infection, drugs, or vaccination. Some consider it to be a variant of Henoch-Schönlein purpura (HSP); there are cases of children aged 2–4 who have symptoms overlapping AHEI and HSP. AHEI is uncommon but reported worldwide. Most cases occur in winter.

Edema of the face is often seen initially, followed suddenly by skin lesions beginning distally and spreading proximally. The patient may have low-grade fever but does not appear toxic. Systemic symptoms are rare, although joint, gastrointestinal (with bloody diarrhea), and renal (with hematuria and proteinuria) involvement may occur. Purpuric lesions can be painful.

Illness lasts 1–3 weeks and resolves without consequence. Recurrences may occur.

Codes

ICD10CM:
P83.39 – Other edema specific to newborn

SNOMEDCT:
78913002 – Edema of newborn

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Last Updated: 05/11/2015
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Acute hemorrhagic edema of infancy - Skin
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Acute hemorrhagic edema of infancy : Facial edema, Edema, Palpable purpura, Symmetric extremities, Targetoid configuration
Clinical image of Acute hemorrhagic edema of infancy
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