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Adrenocortical carcinoma
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Adrenocortical carcinoma

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Contributors: Benjamin L. Mazer MD, MBA
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A malignant tumor of the adrenal cortex. Adrenal carcinomas may be found incidentally on imaging or may be identified after a patient shows signs of endocrine dysfunction, such as hypercortisolism or virilization. About half of adrenal carcinomas do not produce hormones, while the other half produce any combination of the normal adrenal cortical hormones. Adrenal carcinomas have a bimodal epidemiology. They are common in children under 5 and in middle-aged adults. Syndromes such as multiple endocrine neoplasia type 1 are uncommonly the cause of adrenal carcinoma.

Prognosis varies based on staging of the cancer; however, nearly half of all patients have metastases at the time of initial diagnosis. Treatment modalities include surgery, medical adrenal suppression (mitotane), and cytotoxic chemotherapy.

For more information, see OMIM.


C74.90 – Malignant neoplasm of adrenal gland

255035007 – Adrenal carcinoma

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Last Updated: 03/29/2017
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Adrenocortical carcinoma
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Adrenocortical carcinoma : Virilization, Weight gain
Imaging Studies image of Adrenocortical carcinoma
Post-contrast MRI of the abdomen demonstrates heterogeneously enhancing right adrenal mass.
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