African tick bite fever
The disease is characterized by an acute influenza-like illness with myalgias, regional lymphadenopathy, headache, fatigue, and fevers. Neck pain and neck stiffness can be prominent. The acute febrile illness develops 5-7 days after tick exposure. An elevated C-reactive protein, elevated liver function tests, thrombocytopenia, and lymphopenia may be seen during this stage. The febrile illness is typically preceded by eschars forming at the site of the tick bites and a widespread rash seen in about one-third of patients.
A77.1 – Spotted fever due to Rickettsia conorii
406558002 – African tick bite fever
- Mediterranean spotted fever
- African trypanosomiasis (for the fever and malaise)
- Scrub typhus
- Malaria (for the febrile component)
- Typhoid fever
- Cutaneous anthrax (for the eschar)
- Cutaneous leishmaniasis, New World and Old World (for the eschar) – Typically occurs weeks after travel to endemic countries.
- Monkeypox – Usually widespread pseudo-vesicular rash.
- Bubonic plague
- Queensland tick typhus