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Angioimmunoblastic lymphadenopathy
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Angioimmunoblastic lymphadenopathy

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Synopsis

A peripheral T-cell lymphoma that typically affects older adults with median age of 60-65, though it can occur anytime from 20s-80s. Presents with an acute onset of advanced systemic illness including generalized lymphadenopathy, fever, weight loss, anorexia, night sweats, pruritic skin rash, hepatosplenomegaly, edema, ascites, effusions, and arthritis. Cutaneous manifestations are inconsistent, commonly pruritic, and can include macules and papules, purpura, urticaria, nodules, and/or petechiae. Prognosis is often poor with a high mortality rate of 50%-75%.

Laboratory abnormalities can include anemia, polyclonal hypergammaglobulinemia, lactate dehydrogenase elevation, erythrocyte sedimentation rate elevation, positive Coombs test, and thrombocytopenia. There is no standard treatment, though options for initial treatment typically include combination chemotherapy and steroids.

Codes

ICD10CM:
C86.5 – Angioimmunoblastic T-cell lymphoma

SNOMEDCT:
52097008 – Angioimmunoblastic lymphadenopathy

Best Tests

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 01/18/2016
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Angioimmunoblastic lymphadenopathy
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Angioimmunoblastic lymphadenopathy : Fever, Hepatosplenomegaly, Hemolytic anemia, Hypergammaglobulinemia, Lymphadenopathy, Weight loss, Anorexia, Hives , WBC elevated, LYP decreased, EOS increased
Clinical image of Angioimmunoblastic lymphadenopathy
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