Angiosarcoma - Skin
There is a strong male preponderance. Risk factors for the development of angiosarcoma include history of radiotherapy, foreign materials (ie, shrapnel, steel, plastic, Dacron, etc) in the body, chronic lymphedema, and environmental agents such as arsenic and vinyl chloride.
Angiosarcomas are aggressive tumors that tend to grow rapidly, recur locally, and metastasize widely. Prognosis is poor; five-year survival rates are less than 20%. This is due to the biologic behavior of the tumor as well as delays in diagnosis. Initially, lesions may mimic ecchymoses or cellulitis. Medical personnel should maintain a high degree of suspicion and inquire about systemic signs of malignancy (ie, weight loss, fatigue, mass, etc).
C49.9 – Malignant neoplasm of connective and soft tissue, unspecified
403977003 – Angiosarcoma
- Cellulitis or erysipelas
- Breast cancer
- Squamous cell carcinoma
- Epitheloid sarcoma
- Ecthyma gangrenosum
- Lobular capillary hemangioma (pyogenic granuloma)
- Ecchymosis / hematoma
- Other vascular tumors, both benign and malignant, including Kaposi's sarcoma
- Intravascular papillary endothelial hyperplasia
- Angiolymphoid hyperplasia with eosinophilia