Erythema annulare of infancy (EAI) is a nonpruritic eruption of unknown etiology appearing in infants up to a few months of age. Infants are otherwise well, with normal growth and development. The eruptions generally disappear spontaneously, usually within a few weeks to 6 months of age. There may be a waxing and waning course with recurrences every several weeks to months. In some cases, EAI is thought to represent an immunoreactive process in the skin of infants of mothers with an autoimmune disorder, especially systemic lupus erythematosus (SLE). There is also a familial form.