Congenital AT deficiency is passed through autosomal dominant inheritance. Offspring of affected patients will inherit the disorder in approximately 50% of cases. Acquired AT deficiency is caused by conditions or therapies that lower blood levels of AT. It is typically less serious than the hereditary version and can be reversed by treating the causal condition.
Therapy is anticoagulation during thromboembolic events or AT replacement as prophylaxis.
D68.59 – Other primary thrombophilia
36351005 – Antithrombin III deficiency