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Autoerythrocyte sensitization in Child
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Autoerythrocyte sensitization in Child

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Contributors: Anne Seidler MD, MBA, Jeffrey D. Bernhard MD
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Synopsis

Autoerythrocyte sensitization, also known as Gardner-Diamond syndrome or psychogenic purpura, was initially described by Gardner and Diamond in 1955 as an abnormal response to bruising, particularly on the lower extremities of adolescent and adult women. The designation "autoerythrocyte sensitization" is from early reports that patients seemed to react to an intradermal injection of their own erythrocytes. However, later reports were not able to confirm this finding consistently.

The disorder is characterized by bruising without clear precipitating causes or definite trauma. The painful bruises vary in size and may have peculiar or geometric shapes. Associated symptoms include abdominal pain, nausea, vomiting, diarrhea, and headache. Prodromal symptoms such as pain, warmth, or itching at the site prior to the bruising have been described. The bruises resolve in approximately 2 weeks but recur.

Autoerythrocyte sensitization has been associated with psychiatric illness, sometimes subtle and without initial obvious symptoms. Onset may occur following a traumatic event or in the context of severe psychosocial stress. Associated psychiatric abnormalities include depression and anxiety, borderline personality disorder, and obsessive-compulsive disorder.

Codes

ICD10CM:
D69.2 – Other nonthrombocytopenic purpura

SNOMEDCT:
275446004 – Gardner-Diamond syndrome

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Last Updated: 09/11/2017
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Autoerythrocyte sensitization in Child
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Autoerythrocyte sensitization : Abdominal pain, Diarrhea, Headache, Nausea, Painful skin lesions, Ecchymosis
Clinical image of Autoerythrocyte sensitization
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