Blistering distal dactylitis is an acute superficial infection of the palmar fat pad of the finger, usually caused by Group A streptococci (Streptococcus pyogenes) or Staphylococcus aureus. Occasionally, lesions may occur on the proximal digit or palmar surface. School-aged children are most commonly affected, but it may occur in any age group. There are a few reports of blistering distal dactylitis occurring in immunosuppressed or immunocompromised children and adults (eg, HIV, diabetes mellitus, and prednisone use). In some cases, inoculation from nasal bacterial colonization / flora has been suspected (eg, from nose picking).