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Bronchial carcinoid tumor
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Bronchial carcinoid tumor

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Contributors: Shea A. Nagle BA, Mary Anne Morgan MD, Ryan R. Walsh MD, Joshua J. Jarvis MD, Alastair Moore MD, Abhijeet Waghray MD
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Synopsis

Bronchial carcinoid tumors are malignant neuroendocrine neoplasms. They derive from the enterochromaffin cells of the bronchial mucosa and can secrete serotonin, adrenocorticotropic hormone (ACTH), and other neurohormones. Generally, carcinoid tumors are most commonly found in the small bowel, but they can also arise in the colon, appendix, rectum, and proximal airways. While bronchial carcinoid tumors make up around a quarter of all neuroendocrine tumors, they account for around 1% of all lung cancers. Sporadic carcinoid tumors that are well-differentiated have been associated with a loss of heterozygosity at the MEN1 gene (see multiple endocrine neoplasia type 1).

These tumors are graded on histological appearance:
  • Grade 1 describes well-differentiated tumors with a zellballen or nesting appearance.
  • Grade 2 describes cells with atypical appearance or increased mitotic activity in otherwise well-differentiated cells.
  • Grade 3 describes poorly differentiated cells.
Most carcinoid tumors are well-differentiated and associated with a 5-year survival rate of more than 80%. Well-differentiated tumors are also less likely to metastasize than the atypical or poorly differentiated variations.

Bronchial carcinoid tumors occur in adulthood with an approximate average age of diagnosis in the early to mid-50s. Common findings include cough, dyspnea, chest pain, hemoptysis, wheezing (as a result of either airway obstruction or, less often, carcinoid syndrome), and reoccurring pneumonia. ACTH-secreting tumors may result in Cushing syndrome. Excess serotonin secretion may cause carcinoid syndrome; however, carcinoid syndrome is more commonly a manifestation of gastrointestinal carcinoid tumors and may be a sign of metastasis with a primary bronchial carcinoid tumor.

Codes

ICD10CM:
D38.1 – Neoplasm of uncertain behavior of trachea, bronchus and lung

SNOMEDCT:
253003009 – Carcinoid Bronchial Adenoma

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Last Reviewed: 05/07/2019
Last Updated: 05/07/2019
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Bronchial carcinoid tumor
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Bronchial carcinoid tumor : Chest pain, Cough, Dyspnea, Hemoptysis, Wheezing
Imaging Studies image of Bronchial carcinoid tumor
Coronal CT image demonstrates a soft tissue density nodule within the left mainstem bronchus. Bronchoscopic biopsy was consistent with endobronchial carcinoid.
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