Patients with BN will typically be normal to slightly overweight but have a history of large fluctuations in their body mass index (BMI) over time. The purging behaviors of BN affect nearly every organ system in the body.
This summary focuses on the mucocutaneous manifestations; the most common signs and symptoms are:
- Acne – Hormonal changes during binge episodes and periods of weight gain are linked to outbreaks of acne. There is also evidence of increased incidence of polycystic ovary syndrome (PCOS) and hyperandrogenism in BN patients, conditions also associated with acne.
- Eyes and nose – Unexplained subconjunctival hemorrhage, facial petechiae, and recurrent episodes of epistaxis without any history of nasal pathology may be signs of prolonged episodes of retching.
- Oral mucosa – Epithelial erosion from acidic vomitus and frictional trauma from self-induced vomiting result in inflammation and redness of the gingiva, palate, and throat. Atrophic glossitis, mucosal atrophy, and cheilitis (lip inflammation) may also be a sign of vitamin B group deficiency. Vitamin B1, B6, and B12 deficiencies are especially associated with decreased epithelial cell turnover. Patients may also complain of burning or painful sensations of the tongue, referred to as glossodynia.
- Dental – Acidic vomitus leads to poor dentition, including teeth discoloration, frequent dental caries, and tooth sensitivity.
- Salivary – Patients develop sialadenosis, a painless, noninflammatory enlargement of salivary glands, most noticeably the parotid, due to autonomic neuropathy from repetitive vomiting. Salivary dysfunction also leads to complaints of xerostomia (dry mouth). Some patients may develop necrotizing sialometaplasia, a self-limited ulcerative lesion on the posterior hard palate, due to salivary gland necrosis. This resolves on its own in 6-10 weeks.
- Hands – Callus formations on the dorsum of the hand, known as Russell's sign, from repetitive trauma and abrasion to the skin from inducing vomit. Nail biting of varying degrees is also common. Excessive abuse of senna-based laxatives may result in reversible clubbing of fingers.
- Hair loss – Physiological stress and abnormal food intake of BN may result in hair prematurely entering the telogen phase. This thinning or shedding of hair is referred to as telogen effluvium.
- Photosensitivity – Drug-induced phototoxicity may occur from abuse of furosemide and thiazide diuretics.
Careful examination and recognition of risk factors and cutaneous signs can help make an early diagnosis of hidden eating disorders such as BN.
For information on bulimia nervosa, see OMIM.
F50.2 – Bulimia nervosa
78004001 – Bulimia nervosa
- Anorexia nervosa – Less than 85% of expected body weight; intense fear of gaining weight and persistent behavior that interferes with weight gain; may be of the restricting type (diet and excessive exercise) or binge-purge type (self-induced vomiting, misuse of laxatives, diuretics, or enemas).
- Major depressive disorder (MDD) – May occur concurrently with BN; can display significant weight fluctuations and dissatisfaction with body image.
- Hyperemesis gravidarum – A rare complication of pregnancy with intractable nausea and vomiting during the first trimester; look for elevated human chorionic gonadotropin (beta-hCG) levels, low thyrotropin, and elevated T4.
- Androgenic alopecia (male or female pattern)
- Sjögren syndrome – Dry mouth will be accompanied by dry eyes (and vaginal dryness, if female); may also present with bilateral painless parotid enlargement. Serology for antinuclear antibodies ANA, SSA/RO, and SSB/La (most specific) almost always positive in true disease.
- Sarcoidosis – Heerfordt syndrome variant will have parotid gland enlargement in addition to fever, uveitis, and cranial nerve palsy.
- Oral squamous cell carcinoma – Nonresolving oral ulcer; important to rule out before diagnosing necrotizing sialometaplasia.
- Behçet syndrome – Uveitis and oropharyngeal / genital ulcers; gastrointestinal (GI) symptoms of esophageal burning, abdominal pain, vomiting, diarrhea, and constipation.
- Addison disease – Insidious onset with symptoms of fatigue, weakness, diarrhea, nausea, vomiting, and weight loss; ACTH stimulation test will reveal inappropriately low adrenal hormone production levels.
- Acrodermatitis enteropathica – Eczematous dermatitis associated with acquired zinc deficiency; low level of alkaline phosphatase; may be concurrent with severe nutritional deficiency in BN.
- Pellagra (niacin deficiency) – Look for the 4 Ds: dermatitis (phototoxic rash), dementia, diarrhea, and death. May be concurrent with severe nutritional deficiency in BN.
- Hyperthyroidism – Check thyrotropin and free T4 levels.
- Malabsorption – Due to various etiologies (eg, celiac disease, inflammatory bowel disease [ulcerative colitis, Crohn disease]), it may lead to diarrhea, weight loss, anemia, and severe nutritional deficiencies.