Bullous drug eruption in Adult
Alerts and Notices
Synopsis

- Bullous fixed drug eruption – Active fixed drug eruption may become bullous when severe.
- Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN) – A rare, severe, and sometimes life-threatening drug eruption.
- Drug-induced autoimmune blistering diseases (eg, linear IgA bullous dermatosis [LABD], drug-induced bullous pemphigoid, drug-induced pemphigus) – Autoimmune blistering disease that may be drug-induced. Penicillamine and captopril have been implicated in the causation of pemphigus vulgaris; vancomycin, lithium, angiotensin converting enzyme (ACE) inhibitors, and diclofenac have been implicated in LABD; and there are a host of less well-studied drug associations for bullous pemphigoid
- Drug-induced pseudoporphyria – Photoexposed skin fragility and blistering that resembles porphyria cutanea tarda and is usually drug induced.
- Acute generalized exanthematous pustulosis (AGEP) – Characterized by tiny pustules on a background of erythema, AGEP may rarely have bullae and resemble SJS/TEN.
Codes
ICD10CM:L27.1 – Localized skin eruption due to drugs and medicaments taken internally
SNOMEDCT:
402750008 – Bullous dermatosis precipitated by drug treatment
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:06/11/2018
Last Updated:06/12/2018
Last Updated:06/12/2018