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Bullous pemphigoid of childhood in Child
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Bullous pemphigoid of childhood in Child

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Contributors: Craig N. Burkhart MD, Dean Morrell MD, Belinda Tan MD, PhD, Amy Swerdlin MD, Noah Craft MD, PhD
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This summary discusses pediatric patients. Bullous pemphigoid in adults is addressed separately.

Bullous pemphigoid is a chronic autoimmune, subepidermal, vesiculobullous disease that is rarely seen in infants, children, and adolescents (it is most frequently seen in elderly individuals). The disease can occur anywhere, including the oral mucosa. In infants, it may predominate on the palms and soles. In adolescents, it has been reported to resemble adult disease without oral erosions.

On one end of the spectrum, the disease can be severe and generalized, and patients can feel quite ill; on the other end of the spectrum, patients can have a few asymptomatic bullae in localized areas (eg, on the legs). Genital involvement is reported to occur in just under half of cases. Localized bullous pemphigoid of the genital skin is exceedingly rare and is reported in children aged 7-12. Girls are affected more frequently than boys.

In some instances, early bullous pemphigoid lesions will appear as pruritic urticarial papules and plaques.

The condition is often self-limiting, but it can take months to years to resolve.


L12.0 – Bullous pemphigoid

402439006 – Childhood bullous pemphigoid

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Differential Diagnosis & Pitfalls

In infants, bullous pemphigoid may involve only the palms and soles and is in the differential of all non-transient blistering lesions of childhood. Differential diagnosis of localized bullous pemphigoid of the vulva:

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Last Updated: 05/07/2019
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Bullous pemphigoid of childhood in Child
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Bullous pemphigoid of childhood : Tense bullae, Pruritus, Hives , Tense vesicles
Clinical image of Bullous pemphigoid of childhood
A bulla and some crusting and hypopigmented macules on the central face.
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