Cellulite is a common dermatologic condition that is characterized by a dimpled appearance to the skin surface on the posterolateral thighs of postpubertal women.

Cellulite preferentially affects women, estimated as up to 85%-90% in their lifetime. It is thought that the perpendicular orientation of fibrous septae within the adipose tissue in this anatomic location in women gives rise to this phenomenon; in men, these septae run obliquely, accounting for the differing prevalence. It is unclear whether vascular, hormonal, or other factors give rise to these differences. Further pathogenetic findings include enlargement and focal sclerosis of these septae that further tether the skin, giving rise to the topographic irregularities.

Cellulite is asymptomatic and not painful; however, in severe cases, adipose nodules may become more well demarcated and painful. The presence of cellulite can impact a patient's emotional well-being as it affects psychosocial factors such as confidence and self-esteem.