Chondromyxoid fibroma is a very rare, benign, cartilaginous bone tumor of the tubular bones of the lower extremity, including the tibia, femur, calcaneus (foot), patella, and pelvis. It occurs less commonly in the spine, sternum, or skull. It typically develops during the second and third decades of life, with a greater male predominance. Chondromyxoid fibroma has been reported at the site of prior bone injury. It is characterized by localized mild-to-moderate pain and swelling. The tumor may enlarge aggressively. A bony prominence may be palpable.

Once chondrosarcoma and other malignancies are ruled out, management includes removal by curettage or high-speed burr, and filling with bone graft or osseous cement. Nearly one-quarter of curettage and graft procedures were followed by recurrence.