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Chronic recurrent multifocal osteomyelitis
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Chronic recurrent multifocal osteomyelitis

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Contributors: Benjamin L. Mazer MD, MBA
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Chronic recurrent multifocal osteomyelitis (CRMO) is a rare nonbacterial cause of osteomyelitis. It is an autoimmune inflammatory disorder that causes multi-site, relapsing bone inflammation in the absence of typical infectious causes. Patients present with bone pain, swelling, and decreased mobility. CRMO most often occurs in children. CRMO sometimes co-exists with other autoimmune diseases such as inflammatory bowel disease or within a genetic syndrome. Nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and bisphosphonates have all been used to treat CRMO. The disease typically has a relapsing and remitting course.

CRMO is now viewed by many as part of the spectrum of SAPHO syndrome.

For more information, see OMIM.


M86.30 – Chronic multifocal osteomyelitis, unspecified site

240151005 – Chronic multifocal osteomyelitis

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Last Updated: 10/04/2017
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Chronic recurrent multifocal osteomyelitis
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Chronic recurrent multifocal osteomyelitis : Fever, Bone pain, Lytic bone lesions, Recurring episodes or relapses, CRP elevated, ESR elevated, Limited range of motion, Sclerotic bone lesions
Imaging Studies image of Chronic recurrent multifocal osteomyelitis
Hyperostosis and chronic lamellated periosteal reaction involving the medial end of the clavicle. These findings can be seen with CRMO.
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