Neuroblastoma is one of the most common childhood neoplasms and often presents at birth or infancy. Although most cases are sporadic, familial cases inherited in an autosomal dominant fashion have been reported. Cutaneous metastases are common and present as multiple bluish, firm papules and nodules on the trunk and extremities. The lesions blanch after palpation and may remain so for up to 30-60 minutes as a result of catecholamine release. Periorbital ecchymoses may also occur as a result of orbital metastases. The primary lesion is usually located in the upper abdomen and, if large enough, may be palpated or even visible.

The prognosis depends on both the age of the patient and stage of disease. There have been reports of patients with stage IV disease differentiating spontaneously to neural ganglion cells with subsequent regression without treatment.