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Cryofibrinogenemia - Skin
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Cryofibrinogenemia - Skin

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Contributors: Noah Craft MD, PhD, Lindy P. Fox MD, Lowell A. Goldsmith MD, MPH, Michael D. Tharp MD
Other Resources UpToDate PubMed

Synopsis

Cryofibrinogenemia refers to thrombotic occlusive vascular disease resulting from the cold precipitation of cryofibrinogens. Cryofibrinogens are cryoproteins in anticoagulated blood or plasma that are composed of fibrinogens that reversibly precipitate in the cold. The clinical exam and course is similar to cryoglobulinemia. Cryofibrinogenemia can be idiopathic (primary) or associated with malignancy (particularly prostatic cancer), thromboembolic disease, oral contraceptive pills, hyperglycemia, diabetes, pregnancy, and pseudotumor cerebri. There is relatively prompt resolution of skin lesions with immunosuppressive therapy.

For more information, see OMIM.

Codes

ICD10CM:
D89.2 – Hypergammaglobulinemia, unspecified

SNOMEDCT:
10934005 – Cryofibrinogenemia

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 03/29/2017
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Cryofibrinogenemia - Skin
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Cryofibrinogenemia : Acral, Cryofibrinogen increased, Gangrene, Palpable purpura, Skin ulcer, Ecchymosis, Cold intolerance, Painful skin lesion
Clinical image of Cryofibrinogenemia
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