Cutaneous squamous cell carcinoma - Anogenital in
In penile SCC, papillary tumors or flat lesions are seen, and symptoms may include pain, itching, burning, and/or bleeding. Over time the lesions slowly progress into a tumorous mass or slowly infiltrate into deeper tissue.
Elderly individuals are at highest risk for developing SCC. Other risk factors include presence of foreskin, poor hygiene, chronic inflammation, multiple sexual partners, and improper and inadequate management of HPV infection.
SCC is rare in men circumcised at birth. The ratio of penile SCC in uncircumcised men to circumcised men is 5000:1. The distribution of SCC on the male genitalia includes the glans penis (48%), foreskin (21%), corona (6%), or shaft (less than 2%). SCC of the scrotum is much less common than SCC of the penis. Scrotal SCC is a painless slow-progressing nodule. As time goes on the lesion can ulcerate and become indurated, causing pain. Verrucous carcinoma is a rare, well-differentiated, low-grade SCC. It is also referred to as giant condyloma acuminatum of Buschke-Loewenstein, discussed separately. Inguinal lymphadenopathy is seen in 58% of patients. In addition, urethral neoplasms are most often squamous cell carcinomas.
C44.92 – Squamous cell carcinoma of skin, unspecified
402815007 – Squamous cell carcinoma
- Erythroplasia of Queyrat
- Giant condyloma of Buschke-Lowenstein
- Lichen simplex chronicus
- Paget's disease, extramammary
- Lichen sclerosus
- Granuloma Inguinale
- Lymphogranuloma venereum
- Chronic hidradenitis suppurativa
- Bowen's disease
- Basal cell carcinoma
- Condyloma acuminatum
- Lobular capillary hemangioma (pyogenic granuloma)
- Amelanotic melanoma
- Irritated seborrheic keratosis
- Chronic draining or ulcerative lesions
- Hypertrophic lichen planus
- Prurigo nodularis