Genital amebiasis is rare. Pathogenic forms of Entamoeba histolytica cause cutaneous amebiasis. It can be transmitted by having anal intercourse with an individual afflicted with amebic dysentery or via vaginal intercourse with a woman who has vulvovaginal amebiasis. It is possible to contract it as a consequence of enteric amebiasis. Patients with AIDS are at higher risk, and malnourished individuals are more likely to develop cutaneous complications. The incubation period ranges from a few days to several months but is most commonly 2-4 weeks. South America and Southeast Asia have the highest prevalence of amebiasis.

In general, cutaneous disease commonly presents as one or more painful ulcers that can become necrotic. Notably, ulcers tend to enlarge rapidly. If left untreated, progression is rapid and massive destruction of skin and subcutaneous tissues may ensue.