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Cutaneous extramedullary hematopoiesis in Infant/Neonate
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Cutaneous extramedullary hematopoiesis in Infant/Neonate

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Contributors: Vivian Wong MD, PhD, Whitney A. High MD, JD, MEng, Lowell A. Goldsmith MD, MPH
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Synopsis

Cutaneous extramedullary hematopoiesis is a normal occurrence during early embryogenesis, and it occurs until about the fifth month of gestation. Cutaneous extramedullary hematopoiesis in pre-term or full-term neonates is thought to be an accentuation of a normal physiologic process. These lesions resolve spontaneously 3-4 weeks after birth without intervention. Multiple reports suggest also that cutaneous extramedullary hematopoiesis in neonates may be precipitated by congenital infections, erythroblastosis fetalis, and twin transfusion syndrome.

(In adults, cutaneous extramedullary hematopoiesis is a rare cutaneous manifestation of myelofibrosis, where hematopoiesis occurs in the skin rather than the bone marrow, causing polymorphic skin lesions. The condition most often presents as bilateral lower extremity ulcers, but it may also cause papules, nodules, and plaques on any body part. These lesions typically begin as pink erythematous lesions, which become violaceous, hemorrhagic, and ulcerated over time. In addition, the lesions also tend to increase in number and size if the underlying hematological condition remains untreated.)

Codes

ICD10CM:
D75.9 – Disease of blood and blood-forming organs, unspecified

SNOMEDCT:
73241006 – Abnormal hematopoiesis

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Last Updated: 03/12/2019
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Cutaneous extramedullary hematopoiesis in Infant/Neonate
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Cutaneous extramedullary hematopoiesis (Adult) : Red color, Smooth papule, Smooth nodules
Clinical image of Cutaneous extramedullary hematopoiesis
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