Cytomegalovirus infection - Oral Mucosal Lesion
Uncommon in the oral cavity, CMV presents primarily as persistent and progressive ulceration typically occurring in human immunodeficiency virus (HIV) and immunosuppressed patients. In rare cases, CMV manifests in the parotid gland. Patients often have concomitant infection of the gastrointestinal tract (bloody diarrhea) and/or the eyes (chorioretinitis). Other symptoms include lymphadenopathy, hepatosplenomegaly, esophagitis, pneumonia, and meningoencephalitis. Transmission is by body secretions, including saliva, blood, urine, breast milk, semen, and cervical fluid.
With the advent of highly active antiretroviral therapy (HAART), this oral infection has been on the decline in the United States.
Related topic: Cytomegalovirus infection of newborn, Cytomegalovirus retinitis
B25.9 – Cytomegaloviral disease, unspecified
28944009 – Cytomegalovirus infection
- Oral recrudescent herpes simplex virus (HSV) – distinguished by culture or biopsy
- Recurrent aphthous ulcers of the major type – are indistinguishable except that a biopsy would be nonspecific
- Tuberculosis – may appear similar and is distinguished by biopsy
- Non-Hodgkin lymphoma – usually appears as a fleshy mass but may be primarily ulcerated; distinguished by biopsy
- Squamous cell carcinoma – distinguished by biopsy
- Deep fungal infection – distinguished by biopsy