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Demyelinating sensorimotor neuropathy
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Demyelinating sensorimotor neuropathy

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Contributors: Andrea Wasilewski MD, Jamie Adams MD, Richard L. Barbano MD, PhD
Other Resources UpToDate PubMed

Synopsis

A demyelinating sensorimotor neuropathy is a peripheral nerve dysfunction caused by loss of myelination around the axons of neurons. Demyelinating neuropathies cause motor, sensory, or autonomic symptoms. Demyelinating neuropathies affect large diameter axons first, initially producing motor weakness, loss of vibratory sensation, and decreased proprioception.

Demyelinating neuropathies may have an acute or chronic onset. Demyelination can be caused by autoimmune disease, toxins, drug side effects, nutritional deficiencies, infections, paraneoplastic syndromes, or congenital disorders. Charcot-Marie-Tooth disease is the most common cause of hereditary demyelinating polyneuropathy.

Age of onset and treatment vary according to the underlying cause of the neuropathy.

Codes

ICD10CM:
G60.8 – Other hereditary and idiopathic neuropathies

SNOMEDCT:
230656003 – Demyelinating sensorimotor neuropathy

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 11/02/2018
Last Updated: 11/12/2018
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Demyelinating sensorimotor neuropathy
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Demyelinating sensorimotor neuropathy : Distal muscle weakness, Hyporeflexia
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