Desquamative inflammatory vaginitis (DIV) is a rare noninfectious cause of inflammatory vaginitis. Patients present with abundant purulent vaginal discharge that is accompanied by dyspareunia, pruritus, burning, or vestibulovaginal irritation. This condition is mostly seen in patients of Northern European descent of perimenopausal age, but it can be seen in any pre- or post-menopausal woman.

The exact pathogenesis of DIV is unclear; however, there is an altered vaginal microbiome (loss of lactobacilli and the presence of facultative bacteria, such as Escherichia coli and Staphylococcus aureus) and associated inflammation. Whether the dysbiosis precedes or postdates the inflammation is debated.

DIV responds well to treatment, but relapses are common.