Diffuse neonatal hemangiomatosis is characterized by multiple hemangiomatous lesions present at birth or that develop rapidly within the first few days of life. In diffuse neonatal hemangiomatosis, multiple cutaneous and visceral hemangiomas can lead to life-threatening complications. Potential involved organs include the gastrointestinal (GI) tract (leading to GI bleeding), larynx, lungs, central nervous system, spleen, and liver. Arteriovenous (AV) shunts and hepatic involvement can lead to high-output cardiac failure and death. Mortality is estimated to be over 50%. Cerebral hemorrhage is another cause of death. Infants presenting with multiple disseminated hemangiomas need to be evaluated and managed aggressively.