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Discoid lupus erythematosus - External and Internal Eye
See also in: Overview,Hair and Scalp
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Discoid lupus erythematosus - External and Internal Eye

See also in: Overview,Hair and Scalp
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Contributors: Mehdi Rashighi MD, Belinda Tan MD, PhD, Susan Burgin MD, Harvey A. Brown MD
Other Resources UpToDate PubMed

Synopsis

Discoid lupus erythematosus (DLE) is a disfiguring autoimmune skin disease and the most common form of chronic cutaneous lupus erythematosus. It has a characteristic clinical appearance consisting of red, scaly plaques with resulting pigmentary changes and scars; the plaques are frequently found on the face and scalp. DLE most commonly afflicts women in the third and fourth decades of life, although it may occur at any age. Individuals of African and Hispanic descent are at increased risk, and there may be a positive family history of lupus or connective tissue disease.

Discoid rash is one of the 11 diagnostic criteria for systemic lupus erythematosus (SLE), and 20% of patients with SLE will manifest discoid lesions. However, only 5%-10% of patients with DLE demonstrate systemic involvement or will go on to develop SLE. Risk factors for the development of SLE include widespread DLE, arthralgias ⁄ arthritis, nail changes, anemia, leukopenia, an elevated ESR, and a positive test for antinuclear antibodies (ANA).

Lower eyelid involvement occurs in 6% of discoid lupus patients and may present with an associated chronic blepharitis. DLE-associated stromal keratitis has been reported. Periorbital mucinosis of DLE may also present as periorbital edema and erythema.

Squamous cell carcinoma may rarely develop in chronic DLE scars, especially in sun-exposed areas.

Related topics: Tumid lupus erythematosus, Lupus panniculitis, Subacute cutaneous lupus erythematosus, Drug-induced lupus erythematosus

Codes

ICD10CM:
L93.0 – Discoid lupus erythematosus

SNOMEDCT:
200938002 – Discoid lupus erythematosus

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 10/15/2018
Last Updated: 11/27/2018
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Discoid lupus erythematosus - External and Internal Eye
See also in: Overview,Hair and Scalp
Print 6 Images
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Discoid lupus erythematosus : Face, Scalp, Atrophic scar, Sun-exposed distribution
Clinical image of Discoid lupus erythematosus
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