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Potentially life-threatening emergency
Disseminated intravascular coagulation in Child
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Other Resources UpToDate PubMed
Potentially life-threatening emergency

Disseminated intravascular coagulation in Child

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Contributors: Sarah Stein MD, Karen Wiss MD, Sheila Galbraith MD, Craig N. Burkhart MD, Dean Morrell MD, Lynn Garfunkel MD, Nancy Esterly MD
Other Resources UpToDate PubMed

Synopsis

Disseminated intravascular coagulation (DIC) occurs secondary to a variety of far ranging disorders including severe trauma, infection, malignancies (especially leukemia in the pediatric population), severe snakebite reaction, and vascular lesions (kaposiform hemangioendotheliomas, tufted angiomas). The Kasabach-Merritt syndrome is a particular form of DIC where there is consumption of platelets and clotting factors within a kaposiform hemangioendothelioma or tufted angioma.

DIC occurs when there is intravenous coagulation in association with consumption of platelets. Hemolytic anemia and thromboembolism secondary to intravascular coagulation occurs.

The symptoms of DIC can be mild to severe. The onset can be subacute or sudden with associated high fever and development of purpura.

In severe cases, fatality can occur within 2 days.

Codes

ICD10CM:
D65 – Disseminated intravascular coagulation [defibrination syndrome]

SNOMEDCT:
67406007 – Disseminated intravascular coagulation

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 02/16/2017
Last Updated: 02/16/2017
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Potentially life-threatening emergency
Disseminated intravascular coagulation in Child
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View all Images (8)
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Disseminated intravascular coagulation (Acute) : Fibrinogen decreased, Gangrene, Mottled configuration, Ecchymosis, FSP increased, PT prolonged, HR increased, BP decreased, PLT decreased
Clinical image of Disseminated intravascular coagulation
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