- Phenytoin – May cause nystagmus at therapeutic doses, but ataxia is common with supratherapeutic levels. Effects are typically reversible with medication cessation, but permanent cerebellar degeneration can occur with chronic administration.
- Antiepileptic drugs – Carbamazepine, oxcarbazepine, lacosamide, lamotrigine, rufinamide and zonisamide, benzodiazepines, ezogabine, felbamate, and phenobarbital may cause cerebellar ataxia.
- Valproic acid – May cause cerebellar ataxia in the setting of hyperammonemia.
- Chemotherapeutic agents – High-dose cytarabine and asparaginase may cause either permanent or reversible ataxia during medication administration. Acute cerebellar ataxia does not typically occur with fluorouracil administration, but may occur weeks to months after completion of therapy.
- Alcohol – Most common toxin producing ataxia in a midline cerebellar pattern, characterized by ataxia of the legs and gait with relative sparing of the arms.
- Other toxins and poisons – Carbon tetrachloride, heavy metals, phencyclidine (PCP), and toluene may cause cerebellar ataxia.
R27.0 – Ataxia, unspecified
20262006 – Ataxia
- Basilar migraine
- Cerebellar metastasis
- Viral cerebellitis (especially children)
- Cerebellar abscess
- Vitamin E deficiency
- Cerebellar stroke
- Cerebellar hemorrhage
- Vascular malformation
- Paraneoplastic syndrome (especially neuroblastoma in children; lung cancer in adults)
- Multiple sclerosis
- Miller-Fisher variant of acute inflammatory demyelinating polyneuropathy
- Chiari malformation
- Post-concussive syndrome
- Episodic ataxias (type 1, type 2, types 3 and 4)
- Spinocerebellar ataxias
- Fragile X tremor ataxia syndrome (see fragile X syndrome)