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Drug-induced hyperlipasemia
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Drug-induced hyperlipasemia

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Contributors: Michael W. Winter MD, Paritosh Prasad MD
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Synopsis

Drug-induced hyperlipasemia refers to an elevation of lipase attributed to a medication or other drug exposure. Importantly, this does not indicate pancreatitis, as pancreatitis requires 2 of 3 criteria: (1) lipase over 3 times the upper limit of normal, (2) imaging findings suggestive of pancreatitis, and (3) clinical examination consistent with pancreatitis.

Narcotics, thiazide diuretics, oral contraceptives, adrenocorticotropic hormone, and cholinergics are commonly associated with hyperlipasemia. For a list of medications associated with drug-induced hyperlipasemia, see Drug Reaction Data below.

Benign lipasemia will be asymptomatic. If lipase is elevated in the setting of drug-induced pancreatitis, patients will often present with nausea, emesis, and mid-epigastric abdominal pain radiating to the back.

Codes

ICD10CM:
E78.5 – Hyperlipidemia, unspecified

SNOMEDCT:
235944000 – Drug-induced acute pancreatitis

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 01/02/2018
Last Updated: 08/22/2018
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Drug-induced hyperlipasemia
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Drug-induced hyperlipasemia : Lipase elevated
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