ContentsSynopsisCodesDrug Reaction Data
Drug-induced menstrual changes
Other Resources UpToDate PubMed

Drug-induced menstrual changes

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Other Resources UpToDate PubMed


Abnormal menstrual cycle due to use of medications, including hormone therapy, antipsychotics, anticoagulants, antihistamines, alkylating agents, antidepressants, antimetabolites, antifungals, antimicrobials, aromatase inhibitors, monoclonal antibody agents, corticosteroids, and antihypertensives.

Amenorrhea is associated with progesterone and some chemotherapy drugs. Intermenstrual bleeding is associated with progestin-only and combination oral birth control pills as well as estrogen replacement therapy.

Menstrual bleeding has also been linked to use of progesterone and estrogen, prostaglandin agents, intrauterine devices (IUDs), selective serotonin reuptake inhibitors (SSRIs), and methadone therapy. Irregular heavy menstrual bleeding has been linked to use of ginseng and recombinant human relaxin. Drugs that induce hyperprolactinemia are known to cause amenorrhea and galactorrhea. These include antipsychotics, antidepressants, antihypertensives, opioids, and some gastrointestinal medications.


T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter

386804004 – Disorder of menstruation

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Updated: 11/17/2016
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Drug-induced menstrual changes
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Drug-induced menstrual changes : Amenorrhea, Dysmenorrhea, Menorrhagia, Oligomenorrhea
Copyright © 2018 VisualDx®. All rights reserved.