ContentsSynopsisCodesDrug Reaction Data
Drug-induced somnolence
Other Resources UpToDate PubMed

Drug-induced somnolence

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Other Resources UpToDate PubMed


Excessive drowsiness or daytime sleepiness is an adverse effect of certain medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), sedatives, sedative-antidepressants, analgesics, opioids, barbiturates, anticonvulsants, antipsychotics, chemotherapy agents, antihypertensives, antibiotics, antivirals, antihistamines, and benzodiazepines. Combined drugs that cause drowsiness (eg, opioids and benzodiazepines, or other central nervous system depressants) can be life-threatening, as they may depress respiration and cause death.

Management includes medication adjustments or substitutions, lower dosage, slower titration, avoidance of concurrent medications known to cause drowsiness, and allowing several weeks for patients to develop tolerances for medication. Patient conditions such as dehydration and metabolic imbalances can magnify the somnolence caused by medications. A number of medications, including psychostimulants and caffeine, have been found to counteract the symptom of drowsiness in some patients.


T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter

271782001 – Drowsy

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Updated: 07/17/2018
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Drug-induced somnolence
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Drug-induced somnolence : Somnolence
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