The inability of the heart to pump blood effectively, caused by an adverse reaction to a drug. A variety of drug agents have been associated with drug-induced heart failure. Some common noncardiac drugs include (but are not limited to) cocaine, tyrosine kinase inhibitors and other chemotherapeutic agents, beta blockers, NSAIDs, anesthetics, and/or antidepressants. Patients may present with dyspnea on exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, and pulmonary edema on physical exam or chest x-ray. Patients receiving drugs associated with drug-induced heart failure should be monitored closely for cardiovascular effects.