Medications are a common cause of hypotension, particularly in the elderly. Medications most commonly cause orthostatic hypotension. In severe cases, drug-induced orthostatic hypotension can lead to syncope, falls, or ischemia to vital organs. Rapid changes in medications or new illnesses may exacerbate drug-induced orthostatic hypotension. Many drugs are implicated in orthostatic hypotension, but some of the more common ones include calcium channel blockers, beta blockers, diuretics, vasodilators, dopaminergic drugs, and antipsychotics. Discontinuing the offending drug usually resolves the hypotension.