Loss of strength following use of certain medications or substances. Often presenting with fatigue, lethargy, and difficulty performing ordinary tasks such as climbing stairs, walking, bending, or lifting. May be described as diminished muscular strength or general weakness. Substances that may cause weakness include alcohol, corticosteroids, stimulants, opioids, antihypertensives, antibiotics, antivirals, antifungals, antihistamines, anticonvulsants, antipsychotics, antidepressants, monoclonal antibody agents, anxiolytics, antigout agents, antidiabetics, and chemotherapeutic agents.

Management depends on the causative agents and the physiologic impairment. Adjusting medications, eliminating drug interactions, and monitoring thyroid levels and electrolytes, can help reduce the drug-induced adverse effects that cause weakness.

Related topic: Drug-Induced Fatigue