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Emergency: requires immediate attention
Drug-induced hepatotoxicity
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Emergency: requires immediate attention

Drug-induced hepatotoxicity

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Other Resources UpToDate PubMed

Synopsis

Liver damage or impairment caused by the use of prescription and over-the-counter medications or supplements, or exposure to other drugs or chemicals that results in damage to the liver. Drug effect may be predictable or idiosyncratic. On clinical exam, patient may appear asymptomatic or show signs of diminished liver functionality. Drug-induced hepatotoxicity is characterized by abnormal readings on liver tests, and patients may present with jaundice, hepatomegaly (often accompanied by enlarged spleen and thrombocytopenia), and/or cholestasis.

The list of drug associations and supplements is extensive. These include antiretrovirals, anxiolytics, antifungals, biologics, nonsteroidal anti-inflammatory drugs (NSAIDs), statins, and antituberculous and antigout agents. Determination of cause can be challenging, as patients may neglect to report over-the-counter dietary and herbal supplement use. The National Library of Medicine maintains a searchable database, LiverTox, with a comprehensive list of agents and drug classes.

Management calls for discontinuation of suspected medication or substance, continued close monitoring of liver tests, and careful attention to potential drug interactions and adverse effects.

Related topics: Drug-Induced Hepatitis, Drug-Induced Splenomegaly, Drug-Induced Jaundice

Codes

ICD10CM:
K71.9 – Toxic liver disease, unspecified

SNOMEDCT:
197354009 – Toxic liver disease

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 01/18/2017
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Emergency: requires immediate attention
Drug-induced hepatotoxicity
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Drug-induced hepatotoxicity : Dark urine, Fatigue, Fever, Hepatomegaly, Jaundice, Nausea, Vomiting, Alkaline phosphatase elevated, Bilirubin elevated, Malaise, Anorexia, RUQ pain, Pale feces, AST/ALT elevated
Copyright © 2019 VisualDx®. All rights reserved.