ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferencesView all Images (3)
Drug-induced jaundice
Print
Other Resources UpToDate PubMed

Drug-induced jaundice

Print Images (3)
Contributors: Michael W. Winter MD, Paritosh Prasad MD
Other Resources UpToDate PubMed

Synopsis

Jaundice is a yellowing of the skin, mucous membranes, and sclera of the eyes. It is caused by accumulation of bilirubin in these organs. Bilirubin may accumulate due to increased release into the blood or decreased clearance into feces and urine. Hemolysis is the most common cause of increased release into blood, while hepatic and biliary dysfunction are the most common causes of decreased clearance. Drugs may induce jaundice through any of these mechanisms.

Some drugs may induce hemolysis, leading to increased circulating bilirubin. Other drugs can cause hepatotoxicity, leading to hepatocellular damage and subsequent decreased bilirubin conjugation by the liver. Finally, drugs may induce cholestasis or bile duct injury, decreasing excretion of bilirubin. Many prescription medications, illicit drugs, and over-the-counter supplements, either at typical doses or overdoses, have been associated with jaundice from a variety of mechanisms of liver injury.

The hallmark symptom of drug-induced jaundice will be yellowing of the skin. This can occur in the setting of an otherwise asymptomatic patient, or in a patient with sequelae of hepatitis and even liver failure, marked by altered mental status, coagulopathy, and fatigue. Some patients with hyperbilirubinemia will report pruritus.

Codes

ICD10CM:
R17 – Unspecified jaundice

SNOMEDCT:
18165001 – Jaundice

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required

References

Subscription Required

Last Reviewed: 08/10/2018
Last Updated: 07/19/2019
Copyright © 2019 VisualDx®. All rights reserved.
Drug-induced jaundice
Print 3 Images
View all Images (3)
(with subscription)
Drug-induced jaundice : Jaundice
Clinical image of Drug-induced jaundice
Copyright © 2019 VisualDx®. All rights reserved.