ENAMs are more common in individuals with lighter skin phototypes and in those who received renal transplantation or chemotherapy for a hematologic malignancy. There is no sex predilection. The risk for malignant transformation of these nevi is unclear. Concurrent transformation of preexisting nevi into dysplastic nevi has been reported.
T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter
402554002 – Eruptive melanocytic nevi
- Eruptive nevi have also been associated with immunosuppression from AIDS, following organ transplantation, and following blistering in Stevens-Johnson syndrome, bullous pemphigoid, and epidermolysis bullosa.
- Eruptive blue nevi
- Eruptive Spitz nevi
- Familial eruptive lentiginosis / familial generalized lentiginosis without systemic abnormalities
- Generalized lentiginosis – Spontaneous eruption of lentiginosis without a positive family history. While this could be an idiopathic diagnosis, there are numerous reported triggers including pregnancy, trauma, immunosuppression, malignancy, blistering diseases, renal and bone marrow transplantation, mastocytosis, and AIDS.
- Leopard syndrome – Multiple lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonary stenosis, abnormal genitalia, retardation of growth, and sensorineural deafness.
- Carney complex / LAMB – Lentigines (mucous membranes, lips, face, external genitalia), atrial myxoma, mucocutaneous myxoma, and blue nevi.
- Peutz-Jeghers syndrome – Lentigines (perioral and oral), multiple gastrointestinal polyps, and visceral tumors (pancreas, ovary, testes).
- Cronkhite-Canada syndrome – Lentigines (buccal mucosa, face, palmoplantar), alopecia, nail dystrophy, and intestinal polyps.
- Touraine centrofacial lentiginosis – Lentigines (central face and lips, spares mucosa, none elsewhere), bone abnormalities, dysraphia, endocrine disorders, and neurologic disease.
- Inherited patterned lentiginosis in patients of African descent – Lentigines (central face, hands, feet, buttocks; spares mucous membranes), no other associated systemic abnormalities.
- Segmental and agminated lentiginosis – Eruption of grouped lentigines within a segmental pattern in an otherwise healthy individual.
- Laugier-Hunziker syndrome – Benign pigmentary condition with lentigines (buccal mucosa, lips, gums, tongue, palate, neck, abdomen, genitalia, fingers, toes) and longitudinal melanonychia.
- Cantú (hyperkeratosis-hyperpigmentation) syndrome – Rare syndrome with pigmented lesions and palmoplantar hyperkeratosis.
- Bannayan-Riley-Ruvalcaba syndrome – Pigmented genital nevi, macrocephaly, intestinal polyps, hamartomas, and lipomas.