ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferencesView all Images (22)
Erythroplasia of Queyrat
See also in: Anogenital
Print
Other Resources UpToDate PubMed

Erythroplasia of Queyrat

See also in: Anogenital
Print Images (22)
Contributors: Gaurav Singh MD, MPH, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Erythroplasia of Queyrat (EPQ) is a squamous cell carcinoma in situ (SCCIS) of the glans penis. The disorder is rare and comprises less than 1% of malignancies that affect males. It should be considered a type of Bowen disease, which is SCCIS at any location. The lesion is a precursor for invasive squamous cell carcinoma (SCC) and is unlikely to remit spontaneously.

EPQ classically presents as a well-demarcated, velvety, erythematous plaque, but its appearance may be variable.

The entity is considered a high-grade squamous intraepithelial lesion / neoplasia (HSIL) histologically. It is most commonly due to human papillomavirus (HPV) type 16. HPV types 18, 26, 31, 33, and 53 have also been implicated. It is more common in elderly, uncircumcised males. EPQ and penile cancer in general has a much higher incidence in non-Western countries likely due to cultural circumcision habits, as circumcision reduces risk.

Risk factors believed to contribute to the development of EPQ include lack of circumcision, Zoon balanitis, HPV infection, immunosuppression (such as human immunodeficiency virus [HIV] infection), ultraviolet (UV) light exposure, phimosis, multiple sexual partners, smoking, other underlying dermatoses (lichen sclerosis, erosive / hypertrophic lichen planus), and any form of chronic irritation, inflammation, or infection. Examples of chronic insults include trauma, herpes simplex virus infection, heat, friction, trauma, urine, and smegma.

If left untreated, EPQ will eventually develop into invasive SCC in one-third of cases.

Codes

ICD10CM:
D07.4 – Carcinoma in situ of penis

SNOMEDCT:
398768004 – Erythroplasia of Queyrat

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Inflammatory conditions: Infectious conditions: Neoplastic conditions:

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

References

Subscription Required

Last Reviewed: 09/20/2018
Last Updated: 10/16/2018
Copyright © 2019 VisualDx®. All rights reserved.
Erythroplasia of Queyrat
See also in: Anogenital
Print 22 Images Filter Images
View all Images (22)
(with subscription)
 Reset
Erythroplasia of Queyrat : Foreskin, Glans of penis, Skin erosion, Dysuria, Pruritus
Clinical image of Erythroplasia of Queyrat
Copyright © 2019 VisualDx®. All rights reserved.