ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferencesInformation for PatientsView all Images (35)
Exanthematous drug eruption in Infant/Neonate
Print
Other Resources UpToDate PubMed

Exanthematous drug eruption in Infant/Neonate

Print Patient Handout Images (35)
Contributors: Craig N. Burkhart MD, Dean Morrell MD
Other Resources UpToDate PubMed

Synopsis

Exanthematous, or morbilliform, eruptions are the most common of all medication-induced eruptions. They consist of red blanching macules and papules that begin on the head and trunk and spread symmetrically caudally and to the proximal extremities. In severe eruptions, lesions coalesce and may lead to generalized erythroderma. Palms, soles, and mucous membranes may also be involved. Pruritus is common, and fever may occur in more severe reactions.

Onset is usually within 7-14 days of initiating a medication, although it is not uncommon for exanthematous penicillin reactions to develop after 2 weeks from the onset of exposure. Scarlatiniform (pinpoint papular), sandpapery-feeling erythematous lesions may also be caused by medications. In dark-skinned children, postinflammatory hyper- or hypopigmentation may take weeks to months to resolve.

Almost any oral agent can cause an exanthematous reaction, but they are most commonly seen with the use of antibiotics (penicillins and sulfas), allopurinol, phenytoin, barbiturates, chlorpromazine, carbamazepine, gold, d-penicillamine, captopril, naproxen, and piroxicam, among others.

Codes

ICD10CM:
L27.0 – Generalized skin eruption due to drugs and medicaments taken internally

SNOMEDCT:
238814003 – Maculopapular drug eruption

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required

References

Subscription Required

Last Updated: 05/31/2017
Copyright © 2019 VisualDx®. All rights reserved.
Exanthematous drug eruption in Infant/Neonate
Print 35 Images Filter Images
View all Images (35)
(with subscription)
 Reset
Exanthematous drug eruption : Rash, Reaction 0 to 5 days after drug, Reaction 6 to 30 days after drug, Widespread, Pruritus
Clinical image of Exanthematous drug eruption
Copyright © 2019 VisualDx®. All rights reserved.