Fixed drug eruption - Cellulitis
FDE is most commonly solitary, but some individuals may develop multiple patches. There may be an increasing number of patches seen with each exposure. Healing with post-inflammatory hyperpigmentation is common.
Numerous drugs have been implicated in causing FDE. The most commonly associated drug classes include antibiotics (in particular sulfonamides, trimethoprim, fluoroquinolones, and tetracyclines), nonsteroidal anti-inflammatory medications (NSAIDs, including naproxen, ibuprofen, and celecoxib), and barbiturates. Other specifically implicated drugs include amoxicillin, erythromycin, metronidazole, fluconazole, paracetamol (acetaminophen), cetirizine, hydroxyzine, methylphenidate, oral contraceptives, quinine, and phenolphthalein. A nonpigmenting variant is seen with pseudoephedrine.
FDE can be differentiated from cellulitis based on a temporal relationship to taking a commonly offending medication and lack of warmth or spreading.
L27.1 – Localized skin eruption due to drugs and medicaments taken internally
73692007 – Fixed drug eruption
- Erythema multiforme
- Contact dermatitis
- Sweet syndrome
- Cellulitis or erysipelas
- Stevens-Johnson syndrome / toxic epidermal necrolysis
- Insect bite reactions
- Post-inflammatory hyperpigmentation
- Lichen planus
- Bullous impetigo
- Tinea corporis
- Erythema migrans
- Recurrent herpes simplex virus (HSV)
- Bullosis diabeticorum
Last Updated: 06/30/2017